BioGaia probiotic strains –
L. reuteri

BioGaia: The Forefront of Microbial Health Innovation 

BioGaia is a Swedish healthcare company that has been at the forefront of microbiome research for over three decades.

Our dedication to understanding and harnessing the power of beneficial bacteria has led us to develop probiotic products featuring Limosilactobacillus reuteri (formerly known as Lactobacillus reuteri), renowned as one of the most scientifically validated probiotics globally.

Note, there has been taxonomy name change from Lactobacillus to Limosilactobacillus and you will find both names throughout the content.

  • Science is at the core of everything we do.
    Gianfranco Grompone Chief Scientific Officer, BioGaia

BioGaia’s global research network

As a pioneer in the field, BioGaia has been at the forefront of probiotic and microbiome research for more than 30 years.

Our team of microbiologists, metabolism experts, process experts, and those responsible for clinical development collaborate with a comprehensive international network of leading researchers and doctors.

Research institutions and these partnerships allow us to validate our rationally designed probiotic formulations through rigorous clinical trials. Many of our trials are double-blind, randomized, and placebo-controlled, ensuring robust scientific evidence.

 

Biogaia

Over time, BioGaia has conducted research studies together with a number of universities and hospitals worldwide. Click to view a selection our network.

  • Swedish University of Agricultural Sciences, Uppsala, Sweden
  • University of Gothenburg, Sweden l Örebro University, Sweden
  • Texas Children’s Hospital, USA
  • University hospitals in Bari and Turin, Italy
  • Baylor College of Medicine, Houston, USA
  • National University of Singapore
  • University of Leuven, Belgium.

Pioneering microbiome research

The products with L. reuteri are among the most scientifically well-documented probiotics in the world. Health benefits and efficacy have been shown in numerous clinical studies.

To date the efficacy and safety of BioGaia’s different strains of L. reuteri have been shown in:

BioGaia’s probiotic endorsements

7

Guidelines

supporting the use for AGE

6

Guidelines

supporting the use for colic

2

Guidelines

supporting the use for FAP

1

Guideline

supporting the use for infection protection

Guidelines for recommendation in Adults

1

Guideline

supporting the use for antibiotic-associated diarrhea

1

Guideline

supporting the use for HP eradication

1

Guideline

supporting the use for constipation

Introducing L. reuteri: One of the world’s most studied probiotic

BioGaia’s products contain unique and patented strains of the lactic acid bacteria Limosilactobacillus reuteri, formerly known as Lactobacillus reuteri.

L. reuteri is a probiotic species whose natural habitat is the human body. Passed from generation to generation during childbirth and breastfeeding, L. reuteri has co-evolved with humans since the beginning of time.

Every product from BioGaia contains unique L. reuteri strains that provide their own distinct health benefits.

Unfortunately, research shows that modern lifestyles have largely eradicated L. reuteri from the human microbiota in many people living a modern, Western lifestyle. By reintroducing L. reuteri through probiotic solutions, this crucial bacterial culture helps restore the potential of the human microbiome.

Every product from BioGaia contains unique L. reuteri strains that provide their own distinct health benefits.

Why recommend probiotic products with L. reuteri?

  • L. reuteri is one of few bacterial species that has developed in symbiosis with humans. Due to this it naturally colonizes and has a strong adaptation.
  • L. reuteri strains survive through the whole GI tract.
  • BioGaia’s products with L. reuteri are manufactured under controlled conditions and of the highest quality and are 100 % safe to use.
  • The number of live bacteria is guaranteed until expiry.
  • Efficacy and safety are tested and documented in the target populations, from newborns to the elderly.
  • Our probiotics contain viable freeze-dried L. reuteri .
  • The probiotic bacteria are always defined on strain level. 

L. reuteri reaches the gut alive

Probiotics originating from humans, like L. reuteri, possess a unique advantage as they have evolved alongside our physiology, potentially fostering a more symbiotic relationship with our gut microbiota.

This intimate co-evolution may enhance their ability to colonize effectively and exert targeted benefits within the human digestive system, making them particularly effective in promoting gut health.

Live bacteria must survive the journey through the acidic environment of the stomach to reach the gut alive. Our clinical studies show that our carefully selected probiotic strains, such as L. reuteri, are proven to survive and reach where the gut alive.

Antimicrobial properties of  Limosilactobacillus reuteri

Reuterin production

L. reuteri is notable for producing an antimicrobial substance called 3-hydroxypropionaldehyde, or reuterin, which it releases into its surroundings. Reuterin effectively inhibits a range of potentially pathogenic bacteria, as well as some viruses and fungi, by inducing oxidative stress through interaction with thiol groups in these pathogens.

Production conditions

The production of reuterin requires an anaerobic environment and glycerol as a substrate. This production is particularly enhanced when L. reuteri comes into close contact with other microorganisms, such as E. coli.

Additional antimicrobial compounds

In addition to reuterin, L. reuteri, like many other lactic acid bacteria, produces lactic acid and acetic acid during the fermentation of various carbohydrates. These acids contribute to inhibiting potential pathogens by creating an environment with a low pH, which is unfavorable for their growth.

Stringent quality standards

From state-of-the-art manufacturing to storage and distribution, we follow strict guidelines. Our quality control measures ensure that every batch meets safety and efficacy standards.

Individually fermented and freeze-dried, the bacteria in our products remain dormant until they encounter saliva and reach a higher temperature, at which point they awaken, are clinically proven to be ‘alive’, and begin their probiotic effects.

Clinically proven safe for all ages

L. reuteri from BioGaia, has been widely studied in clinical trials and has been shown to have probiotic, health-promoting effects in both children and adults.

Numerous studies and meta-analyses have verified the safety of our L. reuteri strains for human consumption among individuals of all ages.

BioGaia Products

BioGaia offers a range of probiotic products designed to support individuals at every stage of life, from newborns to adults.

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